Partial pressure of carbon dioxide by transcutaneous measurement RIS: Partial pressure for carbon dioxide by arterialized capillary blood gas analysis PFT: Transfer coefficient for carbon monoxide O2pulse: Workload(peak)%pred may be an independent risk factor for the occurrence of SRBD.Īlveolar-arterial oxygen partial pressure difference AHI:ĭiffusion capacity of the lung for carbon monoxide ERS:įorced expiratory volume in one second FVC: Pulmonary vascular limitations may represent the pathophysiological link between IPF and SRBD. In search of predictors for SRBD by logistic regression, workload(peak)%pred was identified as a significant variable ( p = 0.033).
The SRBD subgroup presented with a significantly lower performance (workload(peak)%pred 86.5 vs. SRBD was present in 49% (81% obstructive sleep apnea, 19% central sleep apnea), insomnia in 40%, and periodic leg movements in 47% of subjects. Any kind of sleep disorder was found in 89% of patients. ResultsĪ total of 74 IPF patients were evaluated and 45 patients (11 female, median age 74 years, forced vital capacity 71.3%, DLCO 53.9%) were analyzed. To find predictors for SRBD in IPF, multivariable logistic regression was applied. Patients without and with SRBD were compared. Correlation between continuous variables was assessed via the Pearson correlation coefficient. For pairwise comparison of categorical data, the two-proportion z-test was applied. Exclusion criteria were oxygen supplementation therapy, lung emphysema, and heart failure.
Epworth sleepiness scale, Regensburg insomnia scale, and Pittsburgh sleep quality index were evaluated. In this prospective trial, consecutive patients with stable IPF underwent polysomnography and cardiopulmonary exercise testing.
However, the prevalence of sleep disorders in IPF and the pathophysiological link between SRBD and IPF is unclear. Sleep-related breathing disorders (SRBD) may be associated with a worse prognosis in idiopathic pulmonary fibrosis (IPF).
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